Colistin Sulphate is used in the treatment of severe bacterial infections. It is used to treat certain types of serious infections which are not responding to other antibiotics. Colistin Sulphate is an antibiotic. It kills bacteria by destroying the bacterial cell membrane.

Colistin, also known as polymyxin E, is an antibiotic used as a last-resort for multidrug-resistant Gram negative infections including pneumonia. These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter.

In the poultry and swine production, colistin sulfate is indicated for the prevention and control of gastrointestinal diseases caused by Gram negative bacteria, as is the case of Escherichia coli and Salmonella spp